The Pyruvate-Tricarboxylic Acid Cycle Node

Disorders of pyruvate metabolism and the tricarboxylic acid cycle.

The metabolism of pyruvate in the tricarboxylic acid cycle. II. Tissue characteristic metabolism of pyruvate.

It has been shown previously that the mode of entrance of pyruvate into the tricarboxylic acid cycle of the liver is influenced by the nutritional status of the animal. The distribution of isotopic carbon in glutamic acid after the administration of alanine-2-Cl4 or pyruvate-2-Cl4 is reproducible in a series of rats in the same nutritional status (1, 2). This report describes a comparative stud...

The pyruvate-tricarboxylic acid cycle node: a focal point of virulence control in the enteric pathogen Yersinia pseudotuberculosis.

Despite our increasing knowledge of the specific pathogenicity factors in bacteria, the contribution of metabolic processes to virulence is largely unknown. Here, we elucidate a tight connection between pathogenicity and core metabolism in the enteric pathogen Yersinia pseudotuberculosis by integrated transcriptome and [(13)C]fluxome analysis of the wild type and virulence-regulator mutants. Du...

Tricarboxylic Acid Cycle in

The metabolism of pyruvate in the tricarboxylic acid cycle of developing mammalian liver.

Previous work has indicated that much of the biochemical maturation of the mammalian liver takes place around the time of birth (l-6). In the present study of this critical period, we have investigated the mode of pyruvate utilization in the tricarboxylic acid cycle. Pyruvate enters the tricarboxylic acid cycle in two ways, as acetyl coenzyme A and as a dicarboxylic acid. In the following exper...